Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ipratropium Bromide (Sch 1000) 是毒蕈碱的受体的拮抗剂,可用于 COPD 和哮喘等研究,对 M1、M2 和 M3 受体的结合的IC50值分别为 2.9、2 和 1.7 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 148 | 现货 | ||
50 mg | ¥ 260 | 现货 | ||
100 mg | ¥ 468 | 现货 | ||
200 mg | ¥ 798 | 现货 |
产品描述 | Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema. |
体外活性 | Ipratropium bromide combined with Formoterol partially protects the lungs against the chronic inflammation and airspace enlargement by reducing neutrophilic infiltration possibly via the inhibition of MMP-9 activity. [1] Ipratropium bromide (1 nM) significantly increases [Ca(2+)](i), decreases forward scatter and increases annexin-V-binding. Ipratropium bromide treatment is followed by slight but significant increase of hemolysis. Ipratropium bromide triggers suicidal erythrocyte death or eryptosis, an effect mainly due to stimulation of Ca(2+)-entry. [2] |
体内活性 | Ipratropium dry powder inhalation (DPI) at a dose of 2400 mg/horse is an effective bronchodilator in these horses at rest but it has little effect on the airway calibre during the recovery period. [3] Ipratropium significantly attenuates the lung lesions associated with parenchyma inflammatory cell influx and congestion observed in the cadmium treated rats. Ipratropium bromide partially protects the lungs against the inflammation by reducing neutrophilic infiltration. [4] Ipratropium is an antagonist for pre-junctional muscarinic inhibitory receptors on pulmonary parasympathetic nerves and also confirms its potent antagonist actions on post-junctional muscarinic receptors in the airway smooth muscle in the guinea-pig. [5] Ipratropium decreases the maximal change in pleural pressure during tidal breathing (delta Pplmax) and pulmonary resistance (RL) and increases dynamic compliance (Cdyn) in horse. [6] |
别名 | Sch 1000, 异丙托溴铵, Itrop, Atrovent |
分子量 | 412.37 |
分子式 | C20H30BrNO3 |
CAS No. | 22254-24-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 201.3 mM
DMSO: 50 mg/mL (121.25 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.425 mL | 12.125 mL | 24.2501 mL | 60.6252 mL |
5 mM | 0.485 mL | 2.425 mL | 4.85 mL | 12.125 mL | |
10 mM | 0.2425 mL | 1.2125 mL | 2.425 mL | 6.0625 mL | |
20 mM | 0.1213 mL | 0.6063 mL | 1.2125 mL | 3.0313 mL | |
50 mM | 0.0485 mL | 0.2425 mL | 0.485 mL | 1.2125 mL | |
100 mM | 0.0243 mL | 0.1213 mL | 0.2425 mL | 0.6063 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ipratropium Bromide 22254-24-6 Neuroscience AChR Ipratropium asthma chronic obstructive pulmonary disease Sch 1000 inhibit Inhibitor 异丙托溴铵 Sch-1000 Sch1000 Itrop mAChR Muscarinic acetylcholine receptor ischaemia/reperfusion I/R Atrovent inhibitor